Medical algorithm: Diagnosis and treatment of hypereosinophilic syndrome

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Hypereosinophilic syndrome: diagnosis and treatment.

PURPOSE OF REVIEW Hypereosinophilic syndrome is increasingly recognized as a heterogeneous group of disorders, in some cases with precisely defined pathogenesis, which has led to changes in diagnostic approaches and therapeutic strategies. An update on causes and modern therapy is presented here. RECENT FINDINGS Clonal eosinophilias belong to the group of myeloid malignancies. Karyotypically ...

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Hypereosinophilic syndrome is a heterogeneous group of rare disorders characterized by marked blood or tissue eosinophilia resulting in a wide variety of clinical manifestations. Although the existence of clinical subtypes (or variants) of HES has been appreciated for some time, the recent characterization of some of these variants at the molecular and immunologic levels has demonstrated dramat...

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Idiopathic Hypereosinophilic Syndrome

Idiopathic hypereosinophilic syndrome is a multisystem disease with peripheral blood eosinophilia of at least 6 months duration, multiple organ system involvement, and no evidence for other known causes of eosinophilia. It is characteristically a disease of middle-aged men, often has a poor prognosis and is seldom found during childhood. Heart dicsease, characterized by endomyocardial fibrosis ...

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Hypereosinophilic syndrome and clonal eosinophilia: point-of-care diagnostic algorithm and treatment update.

Acquired eosinophilia is operationally categorized into secondary, clonal, and idiopathic types. Causes of secondary eosinophilia include parasite infections, allergic or vasculitis conditions, drugs, and lymphoma. Clonal eosinophilia is distinguished from idiopathic eosinophilia by the presence of histologic, cytogenetic, or molecular evidence of an underlying myeloid malignancy. The World Hea...

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ژورنال

عنوان ژورنال: Allergy

سال: 2020

ISSN: 0105-4538,1398-9995

DOI: 10.1111/all.14368